Think about reversing irritation, rebuilding your microbiome, extending your life, and glowing from head to toe—all by mendacity in a pressurised oxygen chamber. Biohacker and Blueprint founder Bryan Johnson swears by it. And his Hyperbaric Oxygen Remedy (HBOT) protocol isn’t simply altering his life—it may save yours too.
On this publish, we unpack the jaw-dropping science, outcomes, and long-tail search questions round HBOT remedy, air air pollution injury, and why this protocol may change into the largest anti-aging and brain-boosting secret of 2025.
What Is Hyperbaric Oxygen Remedy (HBOT)?
Hyperbaric Oxygen Remedy (HBOT) is a medical-grade remedy that entails respiratory 100% pure oxygen in a pressurized chamber. It permits the physique to soak up dramatically extra oxygen than regular—as much as 15x greater than respiratory room air.
Consider it like a reset button on your cells. HBOT creates a brief burst of oxidative stress, prompting the physique to restore, regenerate, and rebuild itself extra effectively.
Bryan Johnson’s HBOT Protocol: The Particulars
Bryan underwent a rigorous 90-day HBOT protocol designed for longevity and efficiency, not simply restoration. His actual setup:
- Chamber Strain: 2.0 ATA (Atmospheres Absolute) – the gold normal for deep tissue oxygenation
- Oxygen Supply: 100% medical-grade oxygen (not concentrators)
- Length: 60 classes in 90 days
- Every Session: 90 minutes with 20 minutes oxygen on / 5 minutes off (to create hypoxic signaling)
- Frequency: ~5x per week with 2 relaxation days
- Masks Use: Oxygen by way of masks (not ambient) to keep away from dangers like cataracts
“It’s been essentially the most efficacious remedy we’ve completed since beginning Blueprint,” Bryan stated.
The Outcomes: Why HBOT May Be Revolutionary
Bryan’s post-therapy outcomes had been nothing in need of staggering:
| Well being Marker | Earlier than | After |
|---|---|---|
| Systemic Irritation (hs-CRP) | Low | Undetectable |
| Acromansia (intestine micro organism) | — | ↑ 1000% |
| Brief-Chain Fatty Acids | — | ↑ 250–290% |
| Dementia Marker | — | ↓ 28.6% |
| Pores and skin Elasticity | — | ↑ 144% |
| Telomere Size | — | Elevated (a marker of longevity) |
He even coined the time period “HBOT Pores and skin” to explain the rejuvenation. Neglect fillers—that is cellular-level pores and skin regeneration.
Why Oxygen Remedy Issues In 2025 (Particularly If You’re Respiration Metropolis Air)
Throughout his travels to India and China, Bryan skilled harmful ranges of PM2.5 air air pollution—corresponding to inhaling 3–5 cigarettes a day. This positive particulate matter is so small, it enters your bloodstream, lungs, and mind.
Compared, HBOT floods the physique with therapeutic oxygen. One fights demise, the opposite breathes life.
Curious About HBOT? Right here’s What Folks Are Asking in 2025
What’s hyperbaric oxygen remedy good for?
Hyperbaric oxygen remedy is sweet for lowering irritation, accelerating wound therapeutic, regenerating pores and skin, enhancing intestine well being, supporting mind operate, and even selling telomere lengthening. It’s changing into a go-to for biohackers, longevity seekers, and athletes alike.
Is HBOT secure for long-term use?
Sure, when completed appropriately utilizing medical-grade gear and supervised protocols like Bryan Johnson’s 60-session HBOT routine, it’s thought-about secure. Nonetheless, too frequent or poorly administered classes might result in oxidative stress—so protocol precision issues.
Bryan Johnson hyperbaric chamber outcomes
From undetectable irritation ranges to a 1000% microbiome enhance, pores and skin rejuvenation, and a 28.6% discount in dementia markers—Bryan Johnson’s hyperbaric oxygen chamber outcomes are a number of the most spectacular ever documented within the self-quantified wellness world.
Easy methods to reverse irritation naturally
Alongside HBOT, reversing irritation naturally entails a clear anti-inflammatory weight loss program, common motion, air detox, supplementing with antioxidants (like NAC or glutathione), and eradicating sugar and seed oils.
Greatest biohacking therapies 2025
A few of the greatest biohacking therapies for 2025 embody:
Hyperbaric oxygen remedy (HBOT)
NAD+ infusions
Chilly plunges
Pink gentle remedy
Precision probiotics (like Akkermansia boosters)
Easy methods to enhance air high quality at house
Use HEPA or IQAir filters, swap your HVAC to MERV-13 filters, and monitor PM2.5 ranges with an air high quality tracker. This is likely one of the greatest methods to shield your lungs, mind, and pores and skin day by day.
HBOT for pores and skin glow
HBOT isn’t simply inside—it’s your whole-body facial. Bryan Johnson referred to as it “the very best pores and skin transforming remedy on the earth” due to boosted collagen, elastin, and blood move.
Hyperbaric oxygen for anti-aging
HBOT for anti-aging is gaining traction in longevity circles. It extends telomeres, reduces oxidative stress, improves mitochondrial operate, and should assist reverse organic age markers.
Longevity protocols 2025
The highest longevity protocols for 2025 embody Bryan Johnson’s Blueprint HBOT, low-carb Mediterranean diets, resistance coaching, air cleansing, and superior biomarker monitoring.
Easy methods to detox from air pollution publicity
To detox from air pollution publicity: set up air filters, keep away from exercising open air throughout excessive PM2.5 days, eat antioxidant-rich meals, and complement with glutathione or NAC. HBOT additionally helps oxygenate tissues broken by environmental stress.
Don’t Have a Chamber? Right here’s What You Can Do
If you happen to can’t entry a high-pressure HBOT clinic, right here’s how one can help your air and oxygen well being as we speak:
At-Residence Air Detox Protocol:
- Use an IQAir or Dyson air air purifier
- Set up MERV-13 filters in your HVAC system
- Monitor your air with an indoor high quality tracker
- Keep away from outside train if PM2.5 > 70
- Put on an N95 masks throughout high-pollution days
Dietary supplements That Assist:
- N-Acetylcysteine (NAC) – fights oxidative injury
- Glutathione – helps cleansing
- Omega-3s – reduces irritation
- Quercetin & Curcumin – anti-inflammatory powerhouses
Closing Phrase: Ought to You Strive It?
If you happen to’re severe about dwelling longer, trying youthful, and feeling mentally sharper, HBOT could also be one of the underrated instruments on the market. Whereas analysis remains to be rising, Johnson’s Blueprint protocol is pioneering what the way forward for wellness may appear like.
It’s not only a remedy—it’s a revolution.
References
- Hadanny A, et al. (2020). Hyperbaric oxygen remedy can induce neuroplasticity and telomere lengthening in people. Getting older, 12(22), 22445–22456. https://doi.org/10.18632/aging.202188
- Bryan Johnson’s Blueprint Protocol – Private biohacking journey and quantified analysis by way of https://blueprint.bryanjohnson.com
- American Faculty of Hyperbaric Medication – Overview on scientific makes use of of HBOT. https://achm.org
- NIH Nationwide Library of Medication – “Hyperbaric Oxygen Remedy: An Overview.” https://pubmed.ncbi.nlm.nih.gov/
- IQAir World Air High quality Index – Actual-time PM2.5 monitoring and air pollution impacts. https://www.iqair.com/world-air-quality
